Question 1

What is the purpose of MARs and SARs?

Accepted Answer

A)   To bind to the nuclear matrix
B)   To form loop structure
C)   To condense DNA
D)   All of the answers are correctE) C) and D)
F) None of the above

Question 2

How many origins of replication are there in bacteria?

Accepted Answer

A)   0
B)   1
C)   2
D)   More than twoE) A) and B)
F) All of the above

Question 3

Over winding of the DNA decreases the number of turns in the double helix, and thus results in super coils in the DNA.

Accepted Answer

A) True 
 B)False

Question 4

What is a mechanism of condensation shared by both prokaryotes and eukaryotes?

Accepted Answer

A)   Nucleosomes
B)   Loop domains
C)   30 nm fiber
D)   None of the answers are correctE) A) and C)
F) All of the above

Question 5

Loop domains in prokaryotes involve how many base pairs?

Accepted Answer

A)   10,000
B)   100,000
C)   1000
D)   50,000E) A) and B)
F) A) and C)

Question 6

Turning the DNA helix to the right causes

Accepted Answer

A)   positive supercoiling.
B)   overwinding.
C)   All of the answers are correct.D) A) and B)
E) A) and C)

Question 7

The function of condensin is to

Accepted Answer

A)   cause the chromosomes to uncompact following mitosis.
B)   coat the chromosomes and condense them into heterochromatin through the compaction of radial loops.
C)   hold the DNA to the histone proteins in the nucleosome core particle.
D)   trigger DNA to be compacted in a nucleosome core particle.
E)   None of the answers are correct.F) C) and E)
G) A) and E)

Question 8

The is a strong relationship between organism complexity and genome size in eukaryotes

Accepted Answer

A) True 
 B)False

Question 9

An Alu sequence is an example of what?

Accepted Answer

A)   Retroelement
B)   Transposable element
C)   Highly repetitive DNA
D)   All of the answers are correctE) None of the above
F) A) and C)

Question 10

About how many bases of DNA wrap around a histone complex?

Accepted Answer

A)   
B)   150
C)   200
D)   > 1,000E) All of the above
F) B) and D) B

Question 11

Negative Supercoiling in bacteria

Accepted Answer

A)   makes the chromosomal DNA more compact.
B)   creates tension because of the underwinding of the DNA.
C)   can promote DNA strand separations in small regions.
D)   All of the answers are correct.E) B) and C)
F) B) and D)

Question 12

Unique sequences make up approximately what percent of the human genome?

Accepted Answer

A)   5%
B)   25%
C)   40%
D)   80%E) None of the above
F) B) and C)

Question 13

Which of the following assists the alignment of sister chromatids during metaphase?

Accepted Answer

A)   Radial loop domains
B)   Cohesin
C)   Centromeres
D)   Nucleosomes
E)   CondensinF) B) and C)
G) A) and E)

Question 14

Which of the following is not part of the structure of the nucleosome core particle?

Accepted Answer

A)   It is composed of an octamer of proteins.
B)   There is a linker region between two nucleosomes of about 200 base pairs.
C)   There are two copies each of H2A, H2B, H3 and H4.
D)   The DNA is wrapped around the core slightly over two complete turns.
E)   The DNA wrapped around the core contains 146-147 base pairs.F) D) and E)
G) A) and B)

Question 15

Which of the following is correctly matched with its description?

Accepted Answer

A)   Highly repetitive DNA contains transposable elements and genes that are expressed in abundance and thus have many copies.
B)   Moderately repetitive DNA contains unique sequences, such as genes found in one or a few copies.
C)   Nonrepetitive DNA is composed of thousands of copies of many short repeats.
D)   Moderately repetitive DNA contains retro elements, such as the Alu sequence.
E)   Moderately repetitive DNA contains transposable elements and genes that are expressed in abundance and thus have many copies.F) A) and E)
G) C) and E) E

Question 16

The majority of bacterial DNA is negatively super coiled.

Accepted Answer

A) True 
 B)False

Question 17

How many types of histone proteins are there?

Accepted Answer

A)   4
B)   5
C)   7
D)   8E) B) and C)
F) A) and D)

Question 18

What types of amino acids are most responsible for the binding of DNA to histones?

Accepted Answer

A)   Hydrophobic amino acids
B)   Polar amino acids
C)   Positively charged amino acids
D)   Negatively charged amino acidsE) A) and D)
F) A) and B) C

Question 19

The term genome refers to the complete complement of sequences and genes that an organism possesses.

Accepted Answer

A) True 
 B)False

Question 20

Each radial loop domain may contain between 10 and 100 base pairs of DNA.

Accepted Answer

A) True 
 B)False

Exam 10: Chromosome Organization and Molecular Structure

What is the purpose of MARs and SARs?

Correct AnswerverifiedShow Answer

How many origins of replication are there in bacteria?

Correct AnswerverifiedShow Answer

Over winding of the DNA decreases the number of turns in the double helix, and thus results in super coils in the DNA.

Correct AnswerverifiedShow Answer

What is a mechanism of condensation shared by both prokaryotes and eukaryotes?

Correct AnswerverifiedShow Answer

Loop domains in prokaryotes involve how many base pairs?

Correct AnswerverifiedShow Answer

Turning the DNA helix to the right causes

Correct AnswerverifiedShow Answer

The function of condensin is to

Correct AnswerverifiedShow Answer

The is a strong relationship between organism complexity and genome size in eukaryotes

Correct AnswerverifiedShow Answer

An Alu sequence is an example of what?

Correct AnswerverifiedShow Answer

About how many bases of DNA wrap around a histone complex?

Correct AnswerverifiedB

Negative Supercoiling in bacteria

Correct AnswerverifiedShow Answer

Unique sequences make up approximately what percent of the human genome?

Correct AnswerverifiedShow Answer

Which of the following assists the alignment of sister chromatids during metaphase?

Correct AnswerverifiedShow Answer

Which of the following is not part of the structure of the nucleosome core particle?

Correct AnswerverifiedShow Answer

Which of the following is correctly matched with its description?

Correct AnswerverifiedE

The majority of bacterial DNA is negatively super coiled.

Correct AnswerverifiedShow Answer

How many types of histone proteins are there?

Correct AnswerverifiedShow Answer

What types of amino acids are most responsible for the binding of DNA to histones?

Correct AnswerverifiedC

The term genome refers to the complete complement of sequences and genes that an organism possesses.

Correct AnswerverifiedShow Answer

Each radial loop domain may contain between 10 and 100 base pairs of DNA.

Correct AnswerverifiedShow Answer

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B

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E

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C

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